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Melon glisodin/ GliSODin®


Melon glisodin; GliSODin®

Example of Ingredient Material Labeling

Melon extract (wheat, melon)

Functional Ingredients    

Melon extract, wheat gliadin


This product has been shown to induce 3 antioxidant enzymes (SOD, GPx, Cat) that protect the health of cells and genes.


What are Vauclusian melons?        

These are antioxidant-rich melons that are 3 to 4 times more resistant to decay than ordinary melons and contain 7 times as much amount of the antioxidant enzyme called SOD.


What are antioxidant enzymes?

These enzymes occurring in the living body protect cells against oxidative stress and prevent aging. They are at the top of various antioxidant agents forming a potent antioxidant system in the body. Studies have shown that the activities of the body’s antioxidant enzymes decline with age.

Background of development

The development of melon glisodin (GliSODin ®) has its origin in drugs for injection.

Studies on the medical use of SOD flourished in France and Germany, and a product was marketed as a drug for rheumatism (Orgotein) in Germany. The SOD products at that time were derived from cattle, and the outbreak of mad cow disease in the early 1990s triggered a search for substitute SODs from plant sources. The possibility of oral administration was also pursued at the same time.

Various substances were tested as potential carriers that would protect SOD. It was confirmed that wheat gliadin binds to SOD and remarkably enhances its activity in the body when consumed orally.

In the search for plant materials, a specially bred variety of melon from southern France was found to have a strong SOD activity.

This variety had been bred to produce melons with longer shelf life.

This discovery led to the birth of melon glisodin (GliSODin®), an antioxidant-inducing material consisting of melon from southern France and wheat gliadin.

Wheat gliadin protects melon SOD from digestion by gastric acid, and also promotes the uptake of melon SOD by the immune cells of the intestines.

The combination of these 2 materials is so ideal that a scientist involved in the development of melon glisodin called it “a godsend combination.” It enabled the prominent enhancement of antioxidant enzymes in the body for first time in the world.

Research and collaborating institutions
  • Laboratory of Fundamental and Applied Bioenergetics, Joseph Fourier University, Grenoble, France

  • Intensive Care Unit, Universitätsklinikum Ulm, Germany

  • Faculty of Medicine, University of Paris VI

  • Department of Dermatology, University of Besançon, France

  • Pitié-Salpêtrière Hospital


Safety in food use

  • Acute toxicity study: Single administration to rats at 2,000 mg/kg body weight confirmed the absence of toxicity.
  • Subacute toxicity study: Administration to rates at 2,000 mg/kg body weight/day for 4 weeks confirmed the absence of toxicity.

Other studies: Ames test, etc.


Safety concerning hazardous substances

  • Tests for residual pesticides, arsenic, heavy metals, etc. have been performed.
Past implementations

General foods (excluding beverage)

Supplements (soft capsules, hard capsules, tablets, granulated products, etc.)

Supplements for pets

What will be your choice?

Here are pictures from an experiment that compared the antioxidant property of Vauclusian melon (left) used in GliSODin® (melon glisodin) with that of standard melon (right). While standard melon starts to perish on the 4th day, Vauclusian remains intact and looks fresh even after the passage of one week.

This resistance to rot is not a result of chemical treatment.

It is the manifestation of the Vauclusian melon’s intrinsic power to prevent deterioration, namely, the antioxidant action of SOD. Although standard melons also contain SOD, the levels in Vauclusian melons are higher beyond comparison. The development of GliSODin® (melon glisodin) started with the vision of tapping into this rich source of SOD.


What will be your choice?

You choose GliSODin® (melon glisodin).


In addition to the care from outside, why don’t you start taking melon glisodin to boost the antioxidant power in your body?

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